Effects of high-protein supplementation during cancer therapy: a systematic review and meta-analysis

Oncology
Oncology
  • 03/12/2025 - 12:08 am

This systematic review and meta-analysis evaluated high-protein supplementation (≥10 g/serving) during cancer therapy. Across 35 randomised controlled trials (3701 patients), high-protein supplements reduced weight loss, improved muscle strength, and lowered hospitalisation rates. No significant effect was found on health-related quality of life. Effects on survival, fat mass, and therapy toxicity were inconsistent. Supplements were generally safe and well-tolerated. Most studies had moderate to high risk of bias, so results should be interpreted cautiously. High-protein supplementation may benefit cancer patients, especially those with prior weight loss, but more robust trials are needed.

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