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Desneves, K. et al. 2005. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial

In this clinical study, hospital inpatients with pressure ulcers were randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/energy supplements containing additional arginine, vitamin C and zinc. Subjects receiving the arginine-containing nutritional supplement had a significantly improved rate of pressure ulcer healing over the course of three weeks.

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Munoz et al. 2022. Malnutrition and Pressure Injury Risk in Vulnerable Populations: Application of the 2019 International Clinical Practice Guideline

This article aims to review the latest nutrition care recommendations for the prevention and treatment of pressure injuries, including recommendations tailored to special populations. A secondary objective is to translate nutrition recommendations into actionable steps for the healthcare professional to implement as part of a patient plan of care.

Kurmis, R. et al. 2021. The importance of nutrition in wound management: new evidence from the past decade

Malnutrition is known to contribute to wound development and impair wound healing through reduction in the availability of nutrients to maintain optimal cell maintenance and repair. This review examines studies from the last decade to identify evidence for the effectiveness of nutritional interventions in wound healing. Studies reported identified included 61 primary studies and 6 systematic reviews.

Chapman, B. et al. 2011. Use of an arginine-enriched oral nutrition supplement in the healing of pressure ulcers in patients with spinal cord injuries: An observational study

This pilot study demonstrates the potential for a specialised wound healing nutritional supplement to accelerate the rate of pressure ulcer healing in spinal cord injury patients. A 2.5-fold greater rate of healing was observed in patients consuming the arginine-containing nutritional supplement until full healing compared with those who ceased taking the supplement.

Brewer, S. et al. 2010. Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients

In this clinical study, spinal-cord injured patients with pressure ulcers received a commercial powdered nutritional supplement containing 9g of arginine per day. An approximate 2-fold improvement in pressure ulcer healing was seen in well nourished community spinal patients receiving the arginine-containing nutritional supplement, compared with historical controls.